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Nathan Goodyear

Journal Articles | The Riordan Clinic - 0 views

www.riordanclinic.org/...journal-articles

Riordan Clinic integrative medicine research articles

shared by Nathan Goodyear on 02 Jun 13 - No Cached
  • Nathan Goodyear on 02 Jun 13
     
    Nice review of the research published out of the Riordan Clinic.  This clinic is at the forefront of integrative medicine.
Nathan Goodyear

Curcumin attenuates the development of allergic airway inflammation and hyper-responsiv... - 0 views

www.greenmedinfo.com/...ation-and-hyper-responsiveness

curcumin inflammtion airway allergy allergies NF-KappaB asthma

shared by Nathan Goodyear on 19 Jan 12 - No Cached
  • Nathan Goodyear on 19 Jan 12
     
    curcumin shown to inhibit allergic airway inflammation, through NF-kappaB inhibition.  This has implications in asthma flares.
Nathan Goodyear

Curcumin works synergistically with paclitaxel to inhibit breast cancer in a mouse mode... - 0 views

www.greenmedinfo.com/...ibit-breast-cancer-mouse-model

curcumin NF-KappaB inflammation breast cancer CA

shared by Nathan Goodyear on 19 Jan 12 - No Cached
  • Nathan Goodyear on 19 Jan 12
     
    curcumin shown to augment paclitaxel in breast cancer treatment.  Specifically, NF-kappaB inhibition resulted in reduction in tumor size, decreased tumor cell proliferation, increased apoptosis, and decreased MM-9.
Nathan Goodyear

Franken-Thyroxine Making Your Thyroid Condition Worse? | GreenMedInfo | Blog entry | Na... - 0 views

www.greenmedinfo.com/...g-your-thyroid-condition-worse

thyroid synthroid bioidentical Thyroxine hormone

shared by Nathan Goodyear on 01 Aug 11 - No Cached
  • Nathan Goodyear on 01 Aug 11
     
    synthroid is not biodentical Thyroxine (thyroid) hormone
Nathan Goodyear

The risks associated with mammography screening may be approximately five times higher ... - 0 views

www.greenmedinfo.com/...ve-times-higher-previously-ass

mammogram risks risk radiation breast cancer

shared by Nathan Goodyear on 21 Oct 11 - No Cached
  • Nathan Goodyear on 21 Oct 11
     
    risks associated with mammogram are approximately 5 X higher than previously reported
Nathan Goodyear

Vitamin C: A Concentration-Function Approach Yields Pharmacology and Therapeutic Discov... - 0 views

advances.nutrition.org/...78.full

vitamin C

shared by Nathan Goodyear on 28 Apr 11 - No Cached
  • when vitamin C is ingested by mouth, plasma and tissue concentrations are tightly controlled by at least 3 mechanisms in healthy humans: absorption, tissue accumulation, and renal reabsorption
  • 4th mechanism, rate of utilization, may be important in disease
  • Ascorbate administered intravenously has already been tested in a phase I clinical trial, is in wide use by complementary and alternative medicine (integrative medicine) practitioners, and appears to have minimal side effects in patients who are properly screened.
  • Nathan Goodyear on 28 Apr 11
     
    Fantastic review on IV Vitamin C therapy
Nathan Goodyear

Nutrients | Free Full-Text | Effect of Probiotics on Metabolic Outcomes in Pregnant Wom... - 0 views

www.mdpi.com/...htm

probiotics alternative medicine natural medicine natural therapies diabetes gestational diabetes

shared by Nathan Goodyear on 15 May 17 - No Cached
  • The gut microbial composition is altered during pregnancy
  • probiotic supplements may contribute to the maintenance of bacterial diversity and glucose homeostasis in individuals with metabolic disturbances
  • Assessment of four randomized controlled trials in this review involving 288 pregnant women with GDM found that a 6–8 week probiotic intervention did not improve FBG or LDL-cholesterol levels
  • ...5 more annotations...
  • probiotic supplementation in women with GDM was associated with significant reductions in insulin resistance
  • One proposed method is by the production of short chain fatty acids (SCFAs), generated as a by-product of bacterial fermentation of dietary fibers. SCFAs act as an energy source for intestinal cells and have been found to regulate the production of hormones effecting energy intake and expenditure such as leptin and grehlin
  • Another hypothesized mechanism of SCFA action includes reducing gastrointestinal permeability by upregulating transcription of tight junction proteins, enhancing production of Glucagon-like peptide-2 (GLP-2) which promotes crypt cell proliferation, and reducing inflammation in colonic epithelial cells by increasing PPAR-gamma activation
  • Maintenance of the integrity of the gut barrier minimizes the concentration of lipopolysaccharide (LPS) in circulation
  • LPS is a structural component of gram negative bacterial cell walls, which induces an immune-cell response upon absorption into the human bloodstream, stimulating proinflammatory cytokine production and the onset of insulin resistance and hyperglycemia
  • Nathan Goodyear on 15 May 17
     
    Review (4 studies) found that 6-8 weeks of probiotic therapy of pregnant women with gestational diabetes improved insulin resistance.
  • Open TeleShop on 17 May 17
     
    Hey Dear Check Out Our Online Shopping store in all Over Pakistan.As Seen as On Tv Products Like as Health Beauty,Fitness,Homeware,Kitchenware,And Other Electronic Products in Pakistan Check Out Now| www.openTeleshop.Com
Nathan Goodyear

Metabolic management of brain cancer - 0 views

www.sciencedirect.com/...S0005272810006857

brain cancer

shared by Nathan Goodyear on 17 Jun 13 - No Cached
  • Glutamine is a major metabolic fuel for both brain tumor cells and tumor-associated macrophages (TAMs)
  • the malignant phenotype of brain tumor cells that survive radiotherapy is often greater than that of the cells from the original tumor.
  • Conventional chemotherapy has faired little better than radiation therapy for the long-term management of malignant brain cancer
  • ...37 more annotations...
  • most conventional radiation and brain cancer chemotherapies can enhance glioma energy metabolism and invasive properties, which would contribute to tumor recurrence and reduced patient survival [34].
  • We contend that all cancer regardless of tissue or cellular origin is a disease of abnormal energy metabolism
  • complex disease phenotypes can be managed through self-organizing networks that display system wide dynamics involving oxidative and non-oxidative (substrate level) phosphorylation
  • As long as brain tumors are provided a physiological environment conducive for their energy needs they will survive; when this environment is restricted or abruptly changed they will either grow slower, growth arrest, or perish [8] and [19]
  • New information also suggests that ketones are toxic to some human tumor cells and that ketones and ketogenic diets might restrict availability of glutamine to tumor cells [68], [69] and [70].
  • The success in dealing with environmental stress and disease is therefore dependent on the integrated action of all cells in the organism
  • Tumor cells survive in hypoxic environments not because they have inherited genes making them more fit or adaptable than normal cells, but because they have damaged mitochondria and have thus acquired the ability to derive energy largely through substrate level phosphorylation
  • Cancer cells survive and multiply only in physiological environments that provide fuels (mostly glucose and glutamine) subserving their requirement for substrate level phosphorylation
  • Integrity of the inner mitochondrial membrane is necessary for ketone body metabolism since β-hydroxybutyrate dehydrogenase, which catalyzes the first step in the metabolism of β-OHB to acetoacetate, interacts with cardiolipin and other phospholipids in the inner membrane
  • the mitochondria of many gliomas and most tumors for that matter are dysfunctional
  • Cardiolipin is essential for efficient oxidative energy production and mitochondrial function
  • Any genetic or environmental alteration in the content or composition of cardiolipin will compromise energy production through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • the Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • the Crabtree effect can be reversible, the Warburg effect is largely irreversible because its origin is with permanently damaged mitochondria
  • The continued production of lactic acid in the presence of oxygen is the metabolic hallmark of most cancers and is referred to as aerobic glycolysis or the Warburg effect
  • We recently described how the retrograde signaling system could induce changes in oncogenes and tumor suppressor genes to facilitate tumor cell survival following mitochondrial damage [48].
  • In addition to glycolysis, glutamine can also increase ATP production under hypoxic conditions through substrate level phosphorylation in the TCA cycle after its metabolism to α-ketoglutarate
  • mitochondrial lipid abnormalities, which alter electron transport activities, can account in large part for the Warburg effect
  • targeting both glucose and glutamine metabolism could be effective for managing most cancers including brain cancer
  • The bulk of experimental evidence indicates that mitochondria are dysfunctional in tumors and incapable of generating sufficient ATP through oxidative phosphorylation
  • Cardiolipin defects in tumor cells are also associated with reduced activities of several enzymes of the mitochondrial electron transport chain making it unlikely that tumor cells with cardiolipin abnormalities can generate adequate energy through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • TCA cycle substrate level phosphorylation could therefore become another source of ATP production in tumor cells with impairments in oxidative phosphorylation
  • Caloric restriction, which lowers glucose and elevates ketone bodies [63] and [64], improves mitochondrial respiratory function and glutathione redox state in normal cells
  • DR naturally inhibits glycolysis and tumor growth by lowering circulating glucose levels, while at the same time, enhancing the health and vitality of normal cells and tissues through ketone body metabolism
  • DR is anti-angiogenic
  • DR also reduces angiogenesis in prostate and breast cancer
  • We suggest that apoptosis resistance arises largely from enhanced substrate level phosphorylation of tumor cells and to the genes associated with elevated glycolysis and glutaminolysis, e.g., c-Myc, Hif-1a, etc, which inhibit apoptosis
  • Modern medicine has not looked favorably on diet therapies for managing complex diseases especially when well-established procedures for acceptable clinical practice are available, regardless of how ineffective these procedures might be in managing the disease
  • More than 60 years of clinical research indicates that such approaches are largely ineffective in extending survival or improving quality of life
  • The process is rooted in the well-established scientific principle that tumor cells are largely dependent on substrate level phosphorylation for their survival and growth
  • Glucose and glutamine drive substrate level phosphorylation
  • targeting the glycolytically active tumor cells that produce pro-cachexia molecules, restricted diet therapies can potentially reduce tumor cachexia
  • It is important to recognize, however, that “more is not better” with respect to the ketogenic diet
  • Blood glucose ranges between 3.0 and 3.5 mM (55–65 mg/dl) and β-OHB ranges between 4 and 7 mM should be effective for tumor management
  • Nathan Goodyear on 17 Jun 13
     
    Dr Seyfriend presents his metabolic approach to the treatment of brain cancer.
Nathan Goodyear

Medical education in pharmacogenomics-results from a survey on pharmacogenetic knowledg... - 0 views

www.ncbi.nlm.nih.gov/...PMC5599468

genetics pharmacogenetics

shared by Nathan Goodyear on 17 Jan 18 - No Cached
  • Of participants, 84.3% found pharmacogenomics relevant to their current practice
  • More than two-thirds (65.7%) did not order nor recommend a pharmacogenomic test in the past year
  • pharmacogenomic testing was understood mainly for assessment of the variability of genes affecting drug disposition, metabolism and drug transport leading to individual responses to drugs
  • ...4 more annotations...
  • Pre-emptive, prospective, genotyping to make individualised drug therapy feasible is seen to contribute to personalised medicine
  • assumed to improve drug efficacy and safety
  • Potential benefits of pharmacogenomics (PGx) have been defined such as predicting intended response to medication by more accurate dosing, avoiding adverse drug reactions and therefore enhancing drug safety and reducing health care cost
  • survey among Dutch pharmacists revealed 14.7% recent users of PGx diagnostics [27], whereas in our cohort, the percentage was with 34.3% higher.
  • Nathan Goodyear on 17 Jan 18
     
    Doctors and pharmacists are slow to integrate pharmacogenetics. Good working definition of pharmacogenetics as well.
Nathan Goodyear

Glutathione and Parkinson's Disease - ACAM Integrative Medicine (IM) Blog - 0 views

acam.typepad.com/...ne-and-parkinsons-disease.html

IV glutathione Parkinson's disease treatment therapy

shared by Nathan Goodyear on 14 Dec 11 - No Cached
  • Nathan Goodyear on 14 Dec 11
     
    IV glutathione therapy as adjuvant in people with Parkinson's disease
Nathan Goodyear

SpringerLink - Chinese Journal of Integrative Medicine, Volume 15, Number 1 - 0 views

www.springerlink.com/...c85q1n111434u403

oolong jade green tea weight-loss overweight obesity cholesterol hyperlipidemia

shared by Nathan Goodyear on 25 Nov 11 - No Cached
  • Nathan Goodyear on 25 Nov 11
     
    6 weeks of oolong tea shown to provide weight-loss and improvement in cholesterol 
Nathan Goodyear

The Relationship between Alzheimer's Disease and Diabetes: Type 3 Diabetes? - ACAM Inte... - 0 views

acam.typepad.com/...diabetes-type-3-diabetes-.html

Diabetes Insulin Glucose Alzheimer's disease metabolic syndrome

shared by Nathan Goodyear on 17 Mar 11 - No Cached
  • AD has its foundation in neuroendocrinology
  • Referring to AD as type 3 diabetes has its foundation in the fact that the CNS in AD is characterized by a paucity of insulin and resistance of the insulin receptors
  • Nathan Goodyear on 17 Mar 11
     
    Insulin/Glucose dysregulation and Alzheimer's disease
Nathan Goodyear

Subsequent Cardiac and Stroke Events in Patients with Known... : Evidence-Based Integra... - 0 views

adisonline.com/...roke_Events_in_Patients.7.aspx

EDTA chelation cardiovascular disease vascular

shared by Nathan Goodyear on 06 Jul 11 - No Cached
  • This study indicates that the administration of intravenous EDTA chelation therapy for patients with vascular disease resulted in fewer subsequent cardiac events than primary treatment with CABG, angioplasty or conventional medical therapy.
  • Nathan Goodyear on 06 Jul 11
     
    chelation therapy  proves effective in individuals with vascular disease;  revealing fewer cardiac events when compared to other therapies
Mark Bublitz

What Is Frequency Imprinting? - 0 views

h2oenergyflow.com/...what-is-frequency-imprinting

energy healing what is methods bioenergy chakra vibrational metaphysical medicine polarity therapy integrated bottled water brands company

shared by Mark Bublitz on 06 Feb 15 - No Cached
  • Mark Bublitz on 06 Feb 15
     
    What Is Frequency Imprinting? The act of imprinting water, also known as programming water begins with water that has already been structured. (see what is structured water). Once water is structured in it's hexagonal state it will pick up the template of information you are exposing it to. Most will put a substance into the water to do this.
  • Mark Bublitz on 06 Feb 15
     
    What Is Frequency Imprinting? The act of imprinting water, also known as programming water begins with water that has already been structured. (see what is structured water). Once water is structured in it's hexagonal state it will pick up the template of information you are exposing it to. Most will put a substance into the water to do this.
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